Impacto de series de apnea a diferentes volúmenes pulmonares sobre la sensibilidad al dolor: un ensayo piloto en sujetos sanos
Resumen
Antecedentes: La apnea es una condición caracterizada por la interrupción de la respiración, y se cree que afecta el reflejo barorreceptor en distintos volúmenes pulmonares, influyendo en las respuestas de sensibilidad al dolor.
Objetivos: El presente estudio tuvo como objetivo analizar el efecto de episodios de apnea, realizados con volúmenes pulmonares altos y bajos, sobre la hipoalgesia.
Métodos: Los participantes fueron asignados aleatoriamente a dos grupos: un grupo de apnea a volumen pulmonar alto (GA) y otro a volumen pulmonar bajo (GB). Ambas intervenciones consistieron en series intermitentes de apnea durante un periodo de 6 minutos, mientras caminaban en una cinta. La hipoalgesia se evaluó mediante umbrales de dolor a la presión (UDPs) e intensidad de dolor evocado (DE) en el pulgar, el tibial anterior y la vértebra C7. También se registraron los valores de saturación de oxígeno, frecuencia cardíaca y percepción subjetiva del esfuerzo (PSE) durante las intervenciones.
Resultados: Se incluyeron veintiocho sujetos sanos, asignados en un ratio 1:1 a los grupos GA y GB. Ambos grupos mostraron un aumento en los PPTs en el tibial anterior (F=10,902, p=0.003, η²=0.295) y en C7 (F=7.62, p=0.01, η²=0.227). La intensidad del DE disminuyó en ambos grupos únicamente en el tibial anterior (F=45,455, p=0.043, η²=0.149). No se observaron interacciones significativas entre el tiempo y el grupo en ninguna de las localizaciones corporales, ni para los UDPs ni para la intensidad del DE, lo que indica que la sensibilidad al dolor se modificó de forma similar en ambos grupos.
Conclusiones: Ambas maniobras de apnea, tanto con volumen pulmonar alto como bajo, parecen modificar la sensibilidad al dolor. Sin embargo, los cambios observados fueron similares entre las intervenciones, sin diferencias marcadas entre ellas.
Cómo citar
Referencias
Andersson, J. P. A., Linér, M. H., Fredsted, A., & Schagatay, E. K. A. (2004). Cardiovascular and respiratory responses to apneas with and without face immersion in exercising humans. Journal of Applied Physiology (Bethesda, Md.: 1985), 96(3), 1005–1010. https://doi.org/10.1152/japplphysiol.01057.2002
Basaranoglu, G., Bakan, M., Umutoglu, T., Zengin, S. U., Idin, K., & Salihoglu, Z. (2015). Comparison of SpO2 values from different fingers of the hands. SpringerPlus, 4(1), 561. https://doi.org/10.1186/s40064-015-1360-5
Bijur, P. E., Silver, W., & Gallagher, E. J. (2001). Reliability of the visual analog scale for measurement of acute pain. Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine, 8(12), 1153–1157. https://doi.org/10.1111/j.1553-2712.2001.tb01132.x
Chesterton, L. S., Sim, J., Wright, C. C., & Foster, N. E. (2007). Interrater reliability of algometry in measuring pressure pain thresholds in healthy humans, using multiple raters. The Clinical Journal of Pain, 23(9), 760–766. https://doi.org/10.1097/AJP.0b013e318154b6ae
Costalat, G., Pichon, A., Coquart, J., Bauer, F., & Lemaître, F. (2014). Cardio-ventilatory responses to poikilocapnic hypoxia and hypercapnia in trained breath-hold divers. Respiratory Physiology & Neurobiology, 192, 48–54. https://doi.org/10.1016/j.resp.2013.12.005
Dempsey, J. A. (1999). Exercise-induced arterial hypoxemia. J Appl Physiol, 87, 1997–2006.
Duschek, S., Mück, I., & Reyes Del Paso, G. A. (2007). Relationship between baroreceptor cardiac reflex sensitivity and pain experience in normotensive individuals. International Journal of Psychophysiology: Official Journal of the International Organization of Psychophysiology, 65(3), 193–200. https://doi.org/10.1016/j.ijpsycho.2007.03.012
Edwards, L., Ring, C., McIntyre, D., & Carroll, D. (2001). Modulation of the human nociceptive flexion reflex across the cardiac cycle. Psychophysiology, 38(4), 712–718.
Fiedler, L. S., Machado, L. A., Costa, Y. M., Conti, P. C. R., & Bonjardim, L. R. (2021). Influence of self-reported physical activity and sleep quality on conditioned pain modulation in the orofacial region. Clinical Oral Investigations, 25(3), 1195–1202. https://doi.org/10.1007/s00784-020-03424-z
Hita-Contreras, F., Martínez-López, E., Latorre-Román, P. A., Garrido, F., Santos, M. A., & Martínez-Amat, A. (2014). Reliability and validity of the Spanish version of the Pittsburgh Sleep Quality Index (PSQI) in patients with fibromyalgia. Rheumatology International, 34(7), 929–936. https://doi.org/10.1007/s00296-014-2960-z
Hoos, T., Espinoza, N., Marshall, S., & Arredondo, E. M. (2012). Validity of the Global Physical Activity Questionnaire (GPAQ) in adult Latinas. Journal of Physical Activity & Health, 9(5), 698–705. https://doi.org/10.1123/jpah.9.5.698
Horn-Hofmann, C., Capito, E. S., Wolstein, J., & Lautenbacher, S. (2019). Acute alcohol effects on conditioned pain modulation, but not temporal summation of pain. Pain, 160(9), 2063–2071. https://doi.org/10.1097/j.pain.0000000000001597
Hughes, L., & Patterson, S. D. (2020). The effect of blood flow restriction exercise on exercise-induced hypoalgesia and endogenous opioid and endocannabinoid mechanisms of pain modulation. Journal of Applied Physiology (Bethesda, Md.: 1985), 128(4), 914–924. https://doi.org/10.1152/japplphysiol.00768.2019
Hven, L., Frost, P., & Bonde, J. P. E. (2017). Evaluation of Pressure Pain Threshold as a Measure of Perceived Stress and High Job Strain. PloS One, 12(1), e0167257. https://doi.org/10.1371/journal.pone.0167257
Jafari, H., Van de Broek, K., Plaghki, L., Vlaeyen, J. W. S., Van den Bergh, O., & Van Diest, I. (2016). Respiratory hypoalgesia? Breath-holding, but not respiratory phase modulates nociceptive flexion reflex and pain intensity. International Journal of Psychophysiology: Official Journal of the International Organization of Psychophysiology, 101, 50–58. https://doi.org/10.1016/j.ijpsycho.2016.01.005
Karanasios, S., Lignos, I., Kouvaras, K., Moutzouri, M., & Gioftsos, G. (2023). Low-Intensity Blood Flow Restriction Exercises Modulate Pain Sensitivity in Healthy Adults: A Systematic Review. Healthcare (Basel, Switzerland), 11(5), 726. https://doi.org/10.3390/healthcare11050726
Koltyn, K. F., & Umeda, M. (2006). Exercise, hypoalgesia and blood pressure. Sports Medicine (Auckland, N.Z.), 36(3), 207–214. https://doi.org/10.2165/00007256-200636030-00003
Mendoza-Arranz, C., López-Rebenaque, O., Cabrera-López, C. D., López-Mejías, A., Fierro-Marrero, J., & DeAsís-Fernández, F. (2024). Effects of Apnea-Induced Hypoxia on Hypoalgesia in Healthy Subjects. Sports, 12(11), Article 11. https://doi.org/10.3390/sports12110294
Nardone, M., Teixeira, A. L., Incognito, A. V., Vermeulen, T. D., Shafer, B. M., Millar, P. J., & Foster, G. E. (2020). Within-breath sympathetic baroreflex sensitivity is modulated by lung volume but unaffected by acute intermittent hypercapnic hypoxia in men. American Journal of Physiology. Heart and Circulatory Physiology, 319(1), H213–H221. https://doi.org/10.1152/ajpheart.00296.2020
Pacheco-Barrios, K., Carolyna Gianlorenço, A., Machado, R., Queiroga, M., Zeng, H., Shaikh, E., Yang, Y., Nogueira, B., Castelo-Branco, L., & Fregni, F. (2020). Exercise-induced pain threshold modulation in healthy subjects: A systematic review and meta-analysis. Principles and Practice of Clinical Research (2015), 6(3), 11–28. https://doi.org/10.21801/ppcrj.2020.63.2
Remor, E. (2006). Psychometric properties of a European Spanish version of the Perceived Stress Scale (PSS). The Spanish Journal of Psychology, 9(1), 86–93. https://doi.org/10.1017/s1138741600006004
Reyes del Paso, G. A., Muñoz Ladrón de Guevara, C., & Montoro, C. I. (2015). Breath-Holding During Exhalation as a Simple Manipulation to Reduce Pain Perception. Pain Medicine (Malden, Mass.), 16(9), 1835–1841. https://doi.org/10.1111/pme.12764
Schagatay, E. (2010). Predicting performance in competitive apnea diving, part II: Dynamic apnoea. Diving and Hyperbaric Medicine, 40(1), 11–22.
Shariat, A., Cleland, J. A., Danaee, M., Alizadeh, R., Sangelaji, B., Kargarfard, M., Ansari, N. N., Sepehr, F. H., & Tamrin, S. B. M. (2018). Borg CR-10 scale as a new approach to monitoring office exercise training. Work (Reading, Mass.), 60(4), 549–554. https://doi.org/10.3233/WOR-182762
Shephard, R. J. (2016). Responses of the human spleen to exercise. Journal of Sports Sciences, 34(10), 929–936. https://doi.org/10.1080/02640414.2015.1078488
Silvestrini, N., & Corradi-Dell’Acqua, C. (2023). Distraction and cognitive control independently impact parietal and prefrontal response to pain. Social Cognitive and Affective Neuroscience, 18(1), nsad018. https://doi.org/10.1093/scan/nsad018
Staffe, A. T., Bech, M. W., Clemmensen, S. L. K., Nielsen, H. T., Larsen, D. B., & Petersen, K. K. (2019). Total sleep deprivation increases pain sensitivity, impairs conditioned pain modulation and facilitates temporal summation of pain in healthy participants. PloS One, 14(12), e0225849. https://doi.org/10.1371/journal.pone.0225849
Steinmetz, A., Hacke, F., & Delank, K.-S. (2023). Pressure Pain Thresholds and Central Sensitization in Relation to Psychosocial Predictors of Chronicity in Low Back Pain. Diagnostics, 13(4), Article 4. https://doi.org/10.3390/diagnostics13040786
Suarez-Roca, H., Klinger, R. Y., Podgoreanu, M. V., Ji, R.-R., Sigurdsson, M. I., Waldron, N., Mathew, J. P., & Maixner, W. (2019). Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes. Anesthesiology, 130(4), 634–650. https://doi.org/10.1097/ALN.0000000000002510
Vaegter, H. B., & Jones, M. D. (2020). Exercise-induced hypoalgesia after acute and regular exercise: Experimental and clinical manifestations and possible mechanisms in individuals with and without pain. Pain Reports, 5(5), e823. https://doi.org/10.1097/PR9.0000000000000823
Vervullens, S., Haenen, V., Meert, L., Meeus, M., Smeets, R. J. E. M., Baert, I., & Mertens, M. G. C. A. M. (2022). Personal influencing factors for pressure pain threshold in healthy people: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 139, 104727. https://doi.org/10.1016/j.neubiorev.2022.104727
Wewege, M. A., & Jones, M. D. (2021). Exercise-Induced Hypoalgesia in Healthy Individuals and People With Chronic Musculoskeletal Pain: A Systematic Review and Meta-Analysis. The Journal of Pain, 22(1), 21–31. https://doi.org/10.1016/j.jpain.2020.04.003
Zheng, K., Chen, C., Yang, S., & Wang, X. (2021). Aerobic Exercise Attenuates Pain Sensitivity: An Event-Related Potential Study. Frontiers in Neuroscience, 15, 735470. https://doi.org/10.3389/fnins.2021.735470